7/31/2023 0 Comments Ivcd measurement![]() ![]() īeginning in 2009, the revised World Health Organization (WHO) treatment guidelines were used for the diagnosis and management of dengue. Previous reports showed cardiac involvement in adults with dengue, including myocardial dysfunction (42–47%), arrhythmias (29–63%), and myocarditis (15–29%). Circulatory shock in dengue occasionally occurs during the critical phase or defervescence period. The common complications of dengue in adults are bleeding and organ impairment, but severe plasma leakage leading to circulatory shock is a common cause of death. Recently, there was an epidemic shift in the age pattern of dengue, from children to adults, accompanied by an increase in severity. Approximately 500,000 people with severe dengue require hospitalization, and 2.5% of those affected die annually. ![]() Dengue is rapidly becoming widespread across the globe. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.ĭengue is a mosquito-borne viral disease in humans caused by one of four dengue virus (DENV) serotypes. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper.įunding: Dean’s Fund Research 2013, Faculty of Tropical Medicine, Mahidol University, Bangkok Thailand and Research Fund 2013, the Royal College of Physicians of Thailand. Received: DecemAccepted: Published: May 19, 2016Ĭopyright: © 2016 Thanachartwet et al. ![]() PLoS ONE 11(5):Įditor: Nguyen Tien Huy, Institute of Tropical Medicine (NEKKEN), Nagasaki University, JAPAN (2016) Dynamic Measurement of Hemodynamic Parameters and Cardiac Preload in Adults with Dengue: A Prospective Observational Study. Therefore, dynamic measures to estimate changes in hemodynamic parameters and preload should be monitored to ensure adequate fluid therapy among patients with dengue, particularly patients with dengue shock.Ĭitation: Thanachartwet V, Wattanathum A, Sahassananda D, Wacharasint P, Chamnanchanunt S, Khine Kyaw E, et al. Hypovolemic shock and cardiogenic shock each occurred in approximately half of the patients with dengue shock. Intravascular hypovolemia occurred before defervescence, whereas myocardial dysfunction occurred on the day of defervescence until 2 weeks after fever onset. Hypovolemic shock was observed in 9 (52.9%) patients and cardiogenic shock in 8 (47.1%), with a median (interquartile range) time to shock onset of 6.0 (5.0–6.5) days after fever onset, which was the median day of defervescence. In patients with shock, the mean arterial pressure was significantly lower on day 6 after fever onset ( P = 0.045) and the pulse pressure was significantly lower between days 4 and 7 ( P50% between days 4 and 5 ( P<0.05). Of 162 patients with dengue, 17 (10.5%) experienced dengue shock and 145 (89.5%) did not. From January 2013 to July 2015, we prospectively studied 162 hospitalized adults with confirmed dengue viral infection using non-invasive cardiac output monitoring and bedside ultrasonography to determine changes in hemodynamic and IVC parameters and identify the types of circulatory shock that occur in patients with dengue. Few previous studies have monitored hemodynamic parameters to determine the physiological process of dengue or examined inferior vena cava (IVC) parameters to assess cardiac preload during the clinical phase of dengue. ![]()
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